Induction Chemotherapy for Head and Neck SCC

induction chemotherapy (ICT) through the ages

1960s

• MTX

1970s

• MTX vs cisplatin (response rate 14-41%)
• cisplatin+bleomycin
• cisplatin+bleomycin+[MTX vs vinca]
  • cisplatin+bleomycin+vincristine response rate 80%, CR 29%
• cisplatin+5-FU (PF)
  • response rate 88%, CR 19%
• PF with 120h of 5-FU
  • response rate 93%, Cr 38%
• PF with 120h of 5-FU and higher dose of cisplatin
  • no benefit, more tox